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Updated: Oct 16, 2026

Induction and Monitoring of Adoptive Delayed-Type Hypersensitivity in Rats
Published on: September 30, 2007
Suppression of delayed-type hypersensitivity (DTH) responses in xenografts by pretreatment with ultraviolet
1Department of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University, Japan.
Abstract:
F344 Rat hepatocytes (HCs) that had been exposed to ultraviolet (UV) light were transplanted into the dorsal subcutaneous tissues of Balb/c mice. Four days after the transplantation, the anti-HC delayed-type hypersensitivity (DTH) response was assessed by determining the response to a direct challenge with non-irradiated HCs. The DTH response in mice transplanted with 600 J/m2-UVB-irradiated HCs was suppressed significantly compared with that with non-irradiated HCs. Furthermore, the DTH responses evoked by challenge with non-irradiated HCs were similar to those evoked by UV-irradiated HCs.
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