Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement activation during saturation diving

D M Stevens1, S L Gartner, R R Pearson

  • 1Naval Medical Research Institute, Bethesda, Maryland 20889-5607.

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

John Nash and the Organization of Stroke Care.

AJNR. American journal of neuroradiology·2017
Same author

The pharmacodynamic effects of combined administration of flibanserin and alcohol.

Journal of clinical pharmacy and therapeutics·2017
Same author

Potential of mid-infrared spectroscopy to aid the triage of patients with acute chest pain.

The Analyst·2009
Same author

Estimating radiation doses from multidetector CT using Monte Carlo simulations: effects of different size voxelized patient models on magnitudes of organ and effective dose.

Physics in medicine and biology·2007
Same author

Commentary on viewpoint "Heliox, nitrox, and trimix diving; hyperbaric oxygen treatment; and a flaw in Henry's law".

Journal of applied physiology (Bethesda, Md. : 1985)·2007
Same author

Direct ascent from air and N2-O2 saturation dives in humans: DCS risk and evidence of a threshold.

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2006
Same journal

Side Effects of Hyperbaric Oxygen Therapy.

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2026
Same journal

Avascular Necrosis (Aseptic Osteonecrosis).

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2026
Same journal

Adjunctive Hyperbaric Oxygen in the Treatment of Thermal Burns.

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2026
Same journal

Principles for the Design, Validation, and Acceptance of Decompression Procedures.

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2026
Same journal

A Non-Invasive Gas Exchange Monitor To Assess Swimming-Induced Pulmonary Edema.

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2026
Same journal

Dive Injury and Jellyfish Sting Case Study.

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2026
See all related articles

Complement fragments C3a and C5a increased during saturation dives, correlating with decompression stress and Type I DCS. No link was found between these fragments and high-pressure nervous syndrome (HPNS).

Area of Science:

  • Physiology
  • Marine Biology
  • Biochemistry

Background:

  • Saturation diving involves prolonged exposure to extreme pressures.
  • High-pressure nervous syndrome (HPNS) and Decompression Sickness (DCS) are risks for divers.
  • The role of the complement system in diving-related pathologies is not fully understood.

Purpose of the Study:

  • To investigate the relationship between complement activation fragments (C3a, C5a) and HPNS during saturation diving.
  • To determine if elevated C3a and C5a levels indicate decompression stress in Type I DCS.

Main Methods:

  • Measured C3a and C5a levels in 11 U.S. Navy divers during a 28-day saturation dive to 1,000 fsw.
  • Monitored for symptoms of HPNS and Type I DCS.
  • Analyzed correlations between complement fragment levels, compression, and decompression events.

Related Experiment Videos

Main Results:

  • No correlation was observed between C3a/C5a levels during compression and HPNS occurrence.
  • Increased C3a and C5a levels during saturation diving correlated with decompression stress.
  • Elevated complement fragments were associated with the clinical diagnosis of Type I DCS.

Conclusions:

  • Complement activation, indicated by C3a and C5a, is linked to decompression stress in divers.
  • Complement fragment levels may serve as biomarkers for Type I DCS.
  • The study did not find a link between complement activation and HPNS in this diving cohort.