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Pregnancy associated osteoporosis

F Dunne¹, B Walters, T Marshall

¹Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK.

Clinical Endocrinology

|October 1, 1993

Summary

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Pregnancy-associated osteoporosis may be more common than previously thought, with most cases being idiopathic. A higher prevalence of fractures in mothers suggests a potential genetic link.

Area of Science:

Obstetrics and Gynecology
Endocrinology
Bone Metabolism

Background:

Pregnancy-associated osteoporosis is considered a rare condition.
Limited data exists on the prevalence and characteristics of this condition.

Purpose of the Study:

To investigate the prevalence of osteoporosis associated with pregnancy.
To compile data on the largest group of such patients reported in the literature.

Main Methods:

Identified 35 women with pregnancy-associated osteoporosis.
Matched cases with a control group based on age, weight, height, and calcium status.
Collected detailed medical, obstetric, dietary, and fracture history via questionnaires.

Main Results:

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Twenty-nine cases were idiopathic osteoporosis associated with pregnancy; six had potential secondary causes.
Pain in late first-trimester pregnancy was the most common symptom.
Mothers of affected women showed a significantly higher prevalence of adult fractures at an earlier age compared to controls.

Conclusions:

Idiopathic osteoporosis associated with pregnancy may be more frequent than currently reported.
A potential genetic factor in the etiology of pregnancy-associated osteoporosis is suggested by the increased fracture prevalence in mothers.