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Serum gastrin values in patients with familial adenomatous polyposis
L B Svendsen1, M L Bisgård, J Gustafsen
1Department of Surgical Gastroenterology, Rigshospitalet, Copenhagen, Denmark.
Diseases of the Colon and Rectum
|January 1, 1994
Abstract
Purpose:
An evaluation of the importance of gastrin in the colorectal carcinogenesis in patients with familial adenomatous polyposis was conducted.
Methods:
Blood samples from 168 family members of 26 families were investigated for circulating gastrin. Blood was drawn from 65 affected patients, 66 clinically unaffected first-degree relatives, and 37 spouses.
Results:
We did not find any difference in distribution of serum gastrin among these groups.
Conclusion:
Our results seem to exclude gastrin from being relevant in early carcinogenesis in patients with familial adenomatous polyposis.