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Related Experiment Videos

Endogenous nitric oxide counteracts antigen-induced bronchoconstriction

M G Persson1, S G Friberg, P Hedqvist

  • 1Department of Physiology, Karolinska Institute, Stockholm, Sweden.

European Journal of Pharmacology
|November 16, 1993
PubMed
Summary

Endogenous nitric oxide (NO) inhibits antigen-induced bronchoconstriction. Blocking NO synthesis with L-NAME worsened airway constriction in guinea pigs, an effect reversed by inhaled NO.

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Area of Science:

  • Respiratory physiology
  • Immunology
  • Pharmacology

Background:

  • Antigen challenge triggers bronchoconstriction in sensitized animals.
  • The role of endogenous nitric oxide (NO) in this response is not fully understood.

Purpose of the Study:

  • To investigate the inhibitory effect of endogenous NO on antigen-induced bronchoconstriction.

Main Methods:

  • Ovalbumin-sensitized guinea pigs were challenged with aerosolized ovalbumin.
  • The effect of L-NAME (NO synthesis inhibitor) and inhaled NO on airway pressure was measured.

Main Results:

  • Ovalbumin challenge caused significant, sustained increases in insufflation pressure.
  • L-NAME markedly potentiated this response.

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  • Inhaled NO prevented the potentiating effect of L-NAME.

    • Conclusions:

    • Endogenous NO exerts an inhibitory influence on antigen-induced bronchoconstriction.
    • Modulating NO levels may offer therapeutic potential for allergic airway diseases.