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Assembly of Alzheimer-like filaments from full-length tau protein
R A Crowther1, O F Olesen, M J Smith
1Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.
FEBS Letters
|January 10, 1994
Abstract:
The principal fibrous component of neurofibrillary pathology in Alzheimer's disease, the paired helical filament, is formed from hyperphosphorylated microtubule-associated protein tau. Here we show that recombinant tau protein either in a non-phosphorylated state or following phosphorylation with brain extract can be assembled in vitro into filaments resembling those seen in Alzheimer's disease.