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Related Experiment Videos

Conjunctival involvement in malignancy-associated acanthosis nigricans

H Tabandeh1, S Gopal, M Teimory

  • 1Department of Ophthalmology, St George's Hospital, London, UK.

Eye (London, England)
|January 1, 1993
PubMed
Summary

A rare case of acanthosis nigricans presented with eye symptoms, specifically conjunctivitis, before lung cancer was diagnosed. This highlights a potential, though uncommon, link between skin conditions and underlying malignancies.

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Area of Science:

  • Ophthalmology
  • Dermatology
  • Oncology

Background:

  • Acanthosis nigricans typically manifests as skin hyperpigmentation on the neck, groin, and axillae.
  • Mucosal involvement, such as in the oral cavity, can occur.
  • Conjunctival involvement is an exceptionally rare presentation of acanthosis nigricans, particularly when linked to malignancy.

Observation:

  • A patient presented with bilateral papillary conjunctivitis.
  • The conjunctival condition progressed to hypertrophic papillary conjunctival and lid margin lesions.
  • This ocular presentation was the initial symptom preceding the diagnosis of squamous cell carcinoma of the bronchus.

Findings:

  • The case details acanthosis nigricans associated with bronchus squamous cell carcinoma.

Related Experiment Videos

  • Conjunctival lesions, including papillary hypertrophy, were the presenting feature.
  • Topical corticosteroids and artificial tears provided partial relief for the ocular symptoms.

    • Implications:

    • This case underscores the importance of considering rare presentations of acanthosis nigricans.
    • Ocular manifestations like conjunctivitis may be an early indicator of underlying malignancy.
    • Further investigation into the association between acanthosis nigricans and specific cancers is warranted.