Specular microscopy of the anterior intraocular lens surface

Until recently the cytological assessment of the intraocular lens (IOL) surface was only possible using in vitro cytopathological techniques on explanted lenses or in animal models. Specular microscopy provides an in vivo method for the observation of the IOL surface at high magnification. We have used this technique to examine the IOL surface of 27 normal pseudophakic eyes in the first 3 months following implantation. Cellular deposits consisting of small and giant inflammatory cells were found to be a normal occurrence in otherwise clinically successful cataract surgery. It was also possible to visualise the anterior capsule and its attachment to the IOL surface, an amorphous surface membrane, pigment, surface contaminants (starch granules and fibres), and the markings caused by instrumentation at the time of implantation. The technique of IOL surface specular microscopy therefore provides a useful method for the visualisation of the IOL surface and the cytological reaction that occurs there, and thus allows an assessment of IOL biocompatibility.