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Effects of short chain fatty acid, sodium butyrate, on osteoblastic cells and osteoclastic cells
1Department of Public Health, Nara Medical University, Japan.
The International Journal of Biochemistry
|November 1, 1993
Abstract:
1. Sodium butyrate increased alkaline phosphatase (ALP) activity of cloned osteoblastic cell line MC3T3-E1 by the stimulation of de novo enzyme synthesis. 2. Sodium butyrate did not affect mature osteoblastic cells but affected preosteoblastic cells. 3. Sodium butyrate decreased tartrate resistant acid phosphatase (TRACP)-positive multinucleated cells (MNC) formation from bone marrow cells. This related to the cytotoxicity of sodium butyrate on bone marrow cells.