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Estradiol-17 beta-secreting adrenocortical tumor in a ferret
N S Lipman1, R P Marini, J C Murphy
1Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139.
Journal of the American Veterinary Medical Association
|December 1, 1993
Abstract:
Severe generalized alopecia and marked vulvar enlargement were observed in a 5-year-old spayed ferret with high serum estradiol concentrations. A neoplastic left adrenal gland was removed. Staining of the neoplastic cells for estradiol was demonstrated by use of immunohistochemistry. Clinical findings in this ferret were typical of adrenal-associated endocrinopathy, a syndrome characterized by increased secretion of adrenocortical hormones by hyperplastic or neoplastic adrenal glands.