Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ibuprofen and visual function. Prospective evaluation

J W Melluish, C D Brooks, G Ruoff

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |September 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Management of cholecystitis.

    The Journal of the International College of Surgeons·2010
    Same author

    Efficacy and safety of rofecoxib 12.5 mg and celecoxib 200 mg in two similarly designed osteoarthritis studies.

    Current medical research and opinion·2006
    Same author

    Review article: impact of night-time reflux on lifestyle - unrecognized issues in reflux disease.

    Alimentary pharmacology & therapeutics·2004
    Same author

    Sulfasalazine for the management of juvenile rheumatoid arthritis.

    The Journal of rheumatology·2001
    Same author

    Symmetrical bis(heteroarylmethoxyphenyl)alkylcarboxylic acids as inhibitors of leukotriene biosynthesis.

    Journal of medicinal chemistry·2000
    Same author

    Heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids as leukotriene biosynthesis inhibitors.

    Journal of medicinal chemistry·2000

    This study found no evidence of eye toxicity in patients with osteoarthritis treated with ibuprofen or aspirin for 24 weeks. Eye evaluations confirmed the safety of these common nonsteroidal anti-inflammatory drugs.

    Area of Science:

    • Ophthalmology
    • Rheumatology
    • Pharmacology

    Background:

    • Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and aspirin are commonly used for osteoarthritis.
    • Previous reports suggested potential eye toxicity with ibuprofen therapy.
    • Clinical data on NSAID-induced ocular complications remain important for patient safety.

    Purpose of the Study:

    • To evaluate the ocular safety of ibuprofen (Motrin) compared to aspirin in patients with osteoarthritis.
    • To determine if prolonged NSAID use at 24 weeks leads to observable eye toxicity.
    • To address concerns regarding potential ibuprofen-related eye complications.

    Main Methods:

    • A double-blind study involving 78 patients diagnosed with osteoarthritis.
    • Ophthalmological examinations were conducted before and after a 24-week treatment period.

    Related Experiment Videos

  • Patients received either ibuprofen or aspirin as their treatment regimen.

    • Main Results:

    • No instances of eye toxicity were detected in either the ibuprofen or aspirin treatment groups.
    • Comprehensive eye evaluations showed no adverse effects attributable to either NSAID.
    • The study did not confirm earlier suggestions of ibuprofen-induced eye complications.

    Conclusions:

    • Ibuprofen and aspirin demonstrate a favorable ocular safety profile in patients with osteoarthritis over a 24-week treatment period.
    • Clinical findings do not support the hypothesis of significant eye toxicity associated with ibuprofen therapy.
    • This study reinforces the safety of using ibuprofen and aspirin for managing osteoarthritis symptoms.