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Related Experiment Videos

Chelate root filling cements: biological properties

T H Nielsen1, D Arenholt-Bindslev, M Kilian

  • 1Department of Dental Material, Royal Dental College, Arhus, Denmark.

Journal of Endodontics
|January 1, 1993
PubMed
Summary

This study evaluated HN cement

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Area of Science:

  • Biomaterials Science
  • Dental Materials
  • Microbiology

Background:

  • Dental cements are crucial for various procedures.
  • Evaluating new materials for improved biocompatibility and efficacy is essential.
  • Zinc oxide-eugenol cement serves as a common reference material.

Purpose of the Study:

  • To assess the in vivo and in vitro toxicity of an experimental chelate cement (HN cement).
  • To determine the antibacterial activity of HN cement.
  • To compare HN cement's properties against zinc oxide-eugenol cement.

Main Methods:

  • Subcutaneous injection of cement pastes in rats for in vivo toxicity assessment.
  • In vitro toxicity testing using human fibroblast cultures.
  • Antibacterial activity evaluation using blood agar plates inoculated with Streptococcus sanguis, Staphylococcus aureus, and Prevotella intermedia.

Main Results:

  • HN cement induced significantly less tissue injury in rats compared to zinc oxide-eugenol cement.
  • HN cement exhibited lower toxicity in human fibroblast cultures.
  • Both cements demonstrated antibacterial properties, creating inhibition zones (3-12 mm) against tested bacteria, showing bacteriostatic and bactericidal effects.

Conclusions:

  • HN cement demonstrates reduced in vivo and in vitro toxicity compared to zinc oxide-eugenol cement.
  • HN cement possesses significant antibacterial activity.
  • HN cement shows promise as a potentially safer and effective dental material.

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