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Bisbenzylisoquinoline alkaloids from Cyclea barbata

H Guinaudeau¹, L Z Lin, N Ruangrungsi

¹Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612.

Journal of Natural Products

|November 1, 1993

Summary

Researchers identified two novel bisbenzylisoquinoline alkaloids, (-)-2'-norlimacine and (+)-cycleabarbatine, from Cyclea barbata roots. Several known alkaloids were also identified, expanding our knowledge of this plant's chemical constituents.

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Area of Science:

Phytochemistry
Natural Product Chemistry
Organic Chemistry

Background:

Cyclea barbata is a plant species known to produce various bioactive compounds.
Bisbenzylisoquinoline alkaloids represent a significant class of natural products with diverse pharmacological properties.

Purpose of the Study:

To isolate and characterize new alkaloidal compounds from the roots of Cyclea barbata.
To further investigate the chemical constituents of Cyclea barbata.

Main Methods:

Extraction and isolation of the alkaloidal fraction from Cyclea barbata roots.
Spectroscopic techniques (e.g., NMR, MS) for structure elucidation.
Comparison with known alkaloid standards for identification.

Main Results:

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Two new bisbenzylisoquinoline alkaloids, (-)-2 -norlimacine and (+)-cycleabarbatine, were successfully isolated and characterized.
The known alkaloid (+)-tetrandrine-2 -beta-N-oxide had its N-oxide function configuration assigned.
Several other known alkaloids, including (+)-berbamine and (-)-curine, were identified in the alkaloidal fraction.

Conclusions:

The study expands the known phytochemical profile of Cyclea barbata.
The discovery of new alkaloids highlights the potential of this plant as a source for novel drug leads.
Further research into the biological activities of these isolated alkaloids is warranted.