Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

In vivo evaluation of controlled-release products

S S Hwang1, W Bayne, F Theeuwes

  • 1ALZA Corporation, Palo Alto, CA.

Journal of Pharmaceutical Sciences
|November 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Melt processing of polypropylene-grafted-maleic anhydride/Chitosan polymer blend functionalized with montmorillonite for the removal of lead ions from aqueous solutions.

Scientific reports·2020
Same author

RHS6 coordinately regulates the Th2 cytokine genes by recruiting GATA3, SATB1, and IRF4.

Allergy·2016
Same author

Supine sleep positioning in preterm and term infants after hospital discharge from 2000 to 2011.

Journal of perinatology : official journal of the California Perinatal Association·2016
Same author

Home care practices for preterm and term infants after hospital discharge in Massachusetts, 2007 to 2010.

Journal of perinatology : official journal of the California Perinatal Association·2015
Same author

Implementation of safe sleep practices in the neonatal intensive care unit.

Journal of perinatology : official journal of the California Perinatal Association·2015
Same author

Impact of intra-abdominal fat on surgical outcome and overall survival of patients with gastric cancer.

International journal of surgery (London, England)·2014

This study clarifies deconvolution methods for oral controlled-release products. It shows that while in vivo release is ideal, in vivo absorption can approximate release when absorption is rapid, simplifying in vitro-in vivo correlation.

Area of Science:

  • Pharmacokinetics and Drug Delivery

Background:

  • Evaluating in vivo release rates of oral controlled-release products from plasma drug concentration data is crucial.
  • Existing methods often rely on pharmacokinetic compartmental models to estimate drug absorption.

Purpose of the Study:

  • To theoretically investigate the deconvolution method for determining in vivo release rates from plasma concentration-time profiles.
  • To derive a mathematical expression for the amount of drug remaining at the absorption site.
  • To clarify the relationship between in vivo release and absorption profiles.

Main Methods:

  • Utilized well-accepted pharmacokinetic compartmental models.
  • Derived a mathematical expression assuming a first-order absorption rate process.
  • Analyzed the difference between in vivo release and absorption profiles.

Related Experiment Videos

Main Results:

  • The cumulative amount absorbed can be estimated using Wagner-Nelson or Loo-Riegelman methods.
  • A mathematical relationship was established between the amount at the absorption site and plasma drug concentration.
  • In vivo absorption profiles can approximate in vivo release profiles when absorption is significantly faster than elimination.

Conclusions:

  • The in vivo release profile, not the absorption profile, should ideally correlate with in vitro release data.
  • Using absorption profiles for in vitro-in vivo correlation is advantageous when absorption is rapid, mitigating numerical method noise.
  • This theoretical understanding aids in optimizing the evaluation of oral controlled-release dosage form performance.