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[Comparative clinical study of Neopanpur and Creon]
Orvosi Hetilap
|January 2, 1994
Summary
This study found that Neopanpur and Creon are equally effective in treating chronic pancreatitis symptoms and improving pancreatic function. Both enzyme treatments successfully reduced patient complaints and improved stool quality.
Area of Science:
- Gastroenterology
- Clinical Pharmacology
Background:
- Chronic pancreatitis often leads to maldigestion and requires enzyme replacement therapy.
- Pancreatic enzyme preparations aim to alleviate symptoms and improve nutrient absorption.
Purpose of the Study:
- To compare the clinical efficacy of Neopanpur and Creon in patients with chronic pancreatitis.
- To evaluate the impact of these enzyme preparations on patient-reported symptoms and objective laboratory markers of pancreatic function.
Main Methods:
- A randomized, open-label, crossover study involving 15 patients with chronic pancreatitis.
- Patients received Neopanpur and Creon (10,000 units) for 10-day periods.
- Clinical efficacy was assessed through symptom scoring, stool analysis, and various functional tests including the amylum tolerance test (ATT), H2-breath test, lipjodol-test, Lundh-test, and Schilling-test.
Main Results:
- Both Neopanpur and Creon significantly reduced patient complaints and stool abnormalities.
- Laboratory tests indicated improvements in pancreatic function markers with both treatments.
- No clinically significant differences in efficacy were observed between Neopanpur and Creon.
Conclusions:
- Neopanpur and Creon demonstrate comparable clinical efficacy in managing maldigestion associated with chronic pancreatitis.
- Both enzyme preparations are suitable for treating maldigestion in patients with chronic pancreatic insufficiency.