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Evaluation of povidone-iodine alcoholic solution for operative site disinfection
1Surgical Centre, Okayama University School of Medicine, Japan.
Abstract:
A clinical investigation of povidone-iodine alcoholic solution on disinfectant efficacy at the operative site was carried out in comparison with poloxamer-iodine alcoholic solution and povidone-iodine aqueous solution. Bacterial samples obtained by the cylinder scrub method from 10 cm2 of abdominal skin pre- and post-disinfection were filtered using a millipore membrane and cultured aerobically at 37 degrees C for 48 hours. The antimicrobial efficacy of each product was expressed as the logarithmic reduction value (reduction factor) in resident bacterial counts. Significantly higher reduction factors (RF) of the total resident bacteria were obtained with povidone-iodine ethanol solution (RF 2.02) than with povidone-iodine aqueous solution (RF 1.17). No adverse reaction was observed with either preparation during the study period. It is concluded that povidone-iodine ethanol solution is a reasonable and effective antibacterial agent for pre-operative skin preparation.
Insights
Povidone-iodine ethanol solution demonstrated superior disinfectant efficacy for pre-operative skin preparation compared to aqueous solutions. This effective antibacterial agent significantly reduced resident bacteria without adverse reactions.
Area of Science:
- Microbiology
- Dermatology
- Clinical Medicine
Background:
- Pre-operative skin disinfection is crucial for preventing surgical site infections.
- Various antiseptic formulations are available, each with varying efficacy.
- Povidone-iodine is a widely used antiseptic, but its formulation (alcoholic vs. aqueous) may impact efficacy.
Purpose of the Study:
- To compare the disinfectant efficacy of povidone-iodine alcoholic solution against poloxamer-iodine alcoholic solution and povidone-iodine aqueous solution.
- To evaluate the antimicrobial reduction factor of different antiseptic preparations on abdominal skin.
- To assess the safety and tolerability of these antiseptic solutions during pre-operative skin preparation.
Main Methods:
- A clinical investigation comparing three antiseptic solutions: povidone-iodine ethanol, poloxamer-iodine ethanol, and povidone-iodine aqueous.
- Bacterial samples collected using the cylinder scrub method from abdominal skin before and after disinfection.
- Millipore membrane filtration and aerobic culture at 37°C for 48 hours to determine bacterial counts.
Main Results:
- Povidone-iodine ethanol solution achieved significantly higher logarithmic reduction factors (RF 2.02) compared to povidone-iodine aqueous solution (RF 1.17).
- The study did not report specific RF values for poloxamer-iodine alcoholic solution, focusing the comparison on the two povidone-iodine formulations.
- No adverse reactions were observed with any of the tested antiseptic preparations during the study period.
Conclusions:
- Povidone-iodine ethanol solution is an effective and safe antibacterial agent for pre-operative skin preparation.
- The alcoholic formulation of povidone-iodine offers superior antimicrobial efficacy over its aqueous counterpart.
- These findings support the use of povidone-iodine ethanol solution to enhance surgical site antisepsis.