[Erythrocyte metabolism during chemotherapy in pulmonary tuberculosis patients]

Pre- and posttreatment (13 months after polychemotherapy) activity of key bioenergetic enzymes (LDG and G-6-FDG) and enzymes of antioxidant defense (GPO and GR) was measured in red cells of 88 patients with pulmonary tuberculosis. Pretreatment red cell metabolism of such patients was characterized by compensatory and pathological changes: LDG and GR activity enhanced, while G-6-FDG and GPO activity inhibited. Three months after the treatment LDG, GPO and GR activities completely or partially returned to normal values. G-6-FDG activity in quick treatment responders remained low, in poor response this enzyme activity tended to a decrease. Administration of riboxin as the antihypoxant or ascorbic acid as the antioxidant prevented progressive inhibition of G-6-FDG activity during the chemotherapy and led to a significant improvement of the treatment results.