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Updated: Aug 11, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
[Structure and organization of class I interferon molecules]
Abstract:
The regular structure of class I interferon molecules was proposed using the new method of protein structure investigation--the comparative analysis of amino acids codon roots. It was found out that IFN-alpha and IFN-omega molecules are formed of 5 repeats. Each repeat can be divided into two parts or blocks with regular (alpha-spiral, block A) and irregular (parts of molecules between alpha-spirals, block B) structures. Localization of blocks A and B in IFN-alpha molecules has good correlation with the models of secondary structure organization of IFN-alpha. It is supposed that such a structure of IFN molecules is formed in the evolution process as a result of multiplication of IFN primary gene.
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