Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biomagnetic neurosensors

D Leech1, G A Rechnitz

  • 1Hawaii Biosensor Laboratory, Department of Chemistry, University of Hawaii, Honolulu 96822.

Analytical Chemistry
|November 15, 1993
PubMed
Summary
This summary is machine-generated.

This study introduces biomagnetic field detection to measure nerve activity, successfully detecting the anesthetic lidocaine by observing changes in compound action currents (CACs). This method offers a new approach for screening neurological drugs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reagentless mediated laccase electrode for the detection of enzyme modulators.

Analytical chemistry·2011
Same author

Biomagnetic neurosensors. 4. Design and optimization for analytical use.

Analytical chemistry·2011
Same author

Characterisation of an antibody coated microcantilever as a potential immuno-based biosensor.

Biosensors & bioelectronics·2002
Same author

[Os(bpy)2(PVP)10Cl]Cl polymer and Nafion dual-film modified graphite electrode for the amperometric determination of trace amounts of norepinephrine.

The Analyst·1999
Same author

Optimisation of a reagentless laccase electrode for the detection of the inhibitor azide.

The Analyst·1999
Same author

Electrochemical analysis of the interactions of laccase mediators with lignin model compounds.

Biochimica et biophysica acta·1998
Same journal

The ACS at 150: The History of Analytical Chemistry Publications and a Century of Progress.

Analytical chemistry·2026
Same journal

Machine Learning-Enabled Image Analysis of Complex Chemical Mixtures: Synthetic Urine Droplets as a Test System.

Analytical chemistry·2026
Same journal

H<sub>2</sub>O<sub>2</sub>/Viscosity Tandem-Locked Fluorescent Probes Based on an In Situ Fluorophore Synthesis Strategy for Colitis Imaging and Diagnosis.

Analytical chemistry·2026
Same journal

TopoStitcher: A Geometric-Topological Structure-Guided Stitching Framework for Single-Molecule Localization Microscopy.

Analytical chemistry·2026
Same journal

Noninvasive SERS Immunosensing of Tyrosinase for Melanoma Monitoring via Microneedle Sampling Integrated with Satellite-Structured Bifunctional Nanozymes.

Analytical chemistry·2026
Same journal

Label-Free Electrochemical CRISPR Platform Gated by Allosteric Transcription Factors for Ultrasensitive Small-Molecule Detection.

Analytical chemistry·2026
See all related articles

Area of Science:

  • Neuroscience
  • Biophysics
  • Biosensing

Background:

  • Nerve activity generates biomagnetic fields.
  • Existing biosensing methods for nerve activity can be invasive or lack sensitivity.
  • Compound action current (CAC) reflects synchronized neuronal firing.

Purpose of the Study:

  • To demonstrate the first analytical application of biomagnetic field detection for biosensing at nerve fibers.
  • To establish a non-invasive method for detecting neural conduction.
  • To screen for neuroactive compounds using biomagnetic detection.

Main Methods:

  • Utilized a ferrite core toroid and low-noise amplifier to inductively detect CAC in crayfish giant axons.
  • Stimulated nerve firing to generate detectable biomagnetic signals.

Related Experiment Videos

  • Monitored the disappearance of CAC to detect the presence of lidocaine.

    • Main Results:

    • Successfully detected biomagnetic fields generated by compound action currents in crayfish giant axons.
    • Demonstrated that the local anesthetic lidocaine blocks neuronal conduction, leading to the disappearance of the CAC signal.
    • Validated biomagnetic detection as a viable method for assessing nerve fiber function.

    Conclusions:

    • Biomagnetic field detection offers a novel, sensitive, and non-invasive approach for biosensing at the nerve fiber level.
    • This technique can be applied to screen neurotoxic and neuromodulatory drugs and natural product extracts.
    • The method provides a new tool for understanding nerve conduction and drug interactions.