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Effect of a new calcium antagonist on hemodynamics at rest and exercise loading in patients with essential
S Suzuki1, T Hashimoto, S Kusano
1Nagasaki Prefectural Tarami Hospital, Japan.
Arzneimittel-Forschung
|November 1, 1993
Abstract:
MPC-1304 ((+-)-methyl 2-oxopropyl 1,4-dihydro 2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate, CAS 86780-90-7), a new calcium antagonist, was orally administered to 10 outpatients with mild essential hypertension. It was observed that MPC-1304 inhibited elevations of blood pressure both at rest and under exercise loading without any adverse hemodynamic effects. The findings obtained indicated that MPC-1304 would be clinically useful in the treatment of hypertensive patients undergoing therapy while continuing normal everyday activities including physical exertion.