Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Peptic ulcer: an infectious disease?

L P Andersen¹, H Nielsen

¹Department of Clinical Microbiology, University of Copenhagen, Rigshospitalet, Denmark.

Annals of Medicine

|December 1, 1993

Summary

Helicobacter pylori infection is strongly indicated as the cause of most peptic ulcers. Further research is needed to confirm the temporal relationship and biological gradient for gastric ulcers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Disease activity and damage accrual during the early disease course in a multinational inception cohort of patients with systemic lupus erythematosus.

Lupus·2010

Same author

Bacteraemia with Campylobacter jejuni: no association with the virulence genes iam, cdtB, capA or virB.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2010

Same author

Emerging evidence for Q fever in humans in Denmark: role of contact with dairy cattle.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2009

Same author

Mortality in HIV-infected injection drug users with active vs cleared hepatitis C virus-infection: a population-based cohort study.

Journal of viral hepatitis·2009

Same author

Bacteraemia as a result of Campylobacter species: a population-based study of epidemiology and clinical risk factors.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2009

Same author

Seasonal variation in short-term mortality after surgery for colorectal cancer?

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2009

Area of Science:

Gastroenterology
Infectious Diseases
Epidemiology

Background:

Helicobacter pylori (H. pylori) infection activates human immune responses.
Traditional Koch's criteria are less valuable for assessing H. pylori's role in peptic ulcers.

Purpose of the Study:

To evaluate the causative relationship between H. pylori and peptic ulcers using epidemiological criteria.
To assess the strength of evidence for H. pylori causing duodenal and gastric ulcers.

Main Methods:

Application of modern epidemiological criteria for infectious disease causation.
Review of existing data on association, temporal relationship, biological gradient, plausibility, intervention effects, and coherence.

Main Results:

H. pylori fulfills most epidemiological criteria for duodenal ulcers.
Biological plausibility and coherence are met for both duodenal and gastric ulcers.
Evidence suggests H. pylori causes most peptic ulcers, excluding NSAID-induced and Zollinger-Ellison syndromes.

Conclusions:

H. pylori is a likely cause of most peptic ulcers.
Further studies are required to confirm the temporal relationship and biological gradient for gastric ulcers.
The findings support H. pylori's role in peptic ulcer disease.

Related Experiment Videos