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Intestinal malabsorption presenting with night blindness

M Hasan1, P Finucane

  • 1University Department of Geriatric Medicine, Cardiff Royal Infirmary.

The British Journal of Clinical Practice
|September 1, 1993
PubMed
Summary
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Vitamin A deficiency caused night blindness in a patient with intestinal malabsorption due to duodenal diverticulosis. Treatment with vitamin A and tetracycline resolved the condition by correcting bacterial overgrowth and restoring plasma retinol levels.

Area of Science:

  • Gastroenterology
  • Ophthalmology
  • Nutritional Science

Background:

  • Intestinal malabsorption can lead to nutrient deficiencies, impacting various bodily functions.
  • Vitamin A deficiency is a known cause of visual impairment, including night blindness.
  • Duodenal diverticulosis is a rare condition that can predispose to bacterial overgrowth in the small intestine.

Observation:

  • A patient presented with night blindness attributed to vitamin A deficiency.
  • The underlying cause of malabsorption was identified as duodenal diverticulosis with associated bacterial overgrowth.
  • This specific combination of conditions highlights a complex interplay between gastrointestinal health and nutrient absorption.

Findings:

  • Monthly vitamin A supplementation was initiated.

Related Experiment Videos

  • Bacterial overgrowth was treated with a course of tetracycline.
  • Treatment led to normalized plasma retinol levels and complete resolution of night blindness.

    • Implications:

    • This case underscores the importance of investigating gastrointestinal causes for nutritional deficiencies.
    • Effective management of bacterial overgrowth is crucial in patients with malabsorption syndromes.
    • Restoring vitamin A levels can reverse visual symptoms associated with deficiency, even in complex cases.