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New histological observations in spontaneously developing osteoarthritis in the STR/ORT mouse questioning its
E P Das-Gupta1, T J Lyons, J A Hoyland
1Department of Rheumatology, University of Manchester, UK.
International Journal of Experimental Pathology
|December 1, 1993
Abstract:
Naturally developing spontaneous osteoarthritis (OA) is seen in a number of small animals one of which is the STR/ORT mouse, an accepted model of human OA. A histological evaluation of the patello-femoral joints of 37 male STR/ORT mice has shown features that are inconsistent with the disease in human joints. These include the presence of a prominent acute and chronic synovial inflammatory infiltrate. Such findings call into question the proposed aetiology of the arthropathy in this strain of mouse and its acceptability as a model of human primary OA.