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Reverse transcriptase activity in extracts of human prostatic tissues

L Job, W A Carter, S K Arya

    Oncology
    |January 1, 1978
    PubMed
    Summary
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    Human prostate tissue extracts show oncornavirus-like reverse transcriptase activity. This enzyme, crucial in retroviruses, was detected across normal, hyperplastic, and cancerous prostate tissues.

    Area of Science:

    • Oncology
    • Virology
    • Biochemistry

    Background:

    • Human prostatic tissues can harbor oncornavirus-like reverse transcriptase activity.
    • This activity is associated with retroviral replication mechanisms.

    Purpose of the Study:

    • To isolate and characterize reverse transcriptase activity in human prostatic tissue extracts.
    • To determine the prevalence of this activity in normal, hyperplastic, and cancerous prostate tissues.

    Main Methods:

    • Tissue extracts were analyzed using equilibrium sucrose density gradient centrifugation.
    • Phosphocellulose chromatography was employed for enzyme isolation.
    • Enzyme activity was assessed using poly (Cm) as a template and specific inhibitors.

    Main Results:

    Related Experiment Videos

    • Oncornavirus-like reverse transcriptase activity was successfully isolated from human prostatic tissue extracts.
    • The enzyme utilized poly (Cm) and was inhibited by known reverse transcriptase inhibitors.
    • Activity was detected in 1/4 normal, 5/6 hyperplastic, and 2/2 adenocarcinoma specimens.

    Conclusions:

    • Virus-like reverse transcriptase activity is present in various human prostate tissues, including cancerous ones.
    • These findings suggest potential roles for retroviral elements or related enzymes in prostate pathobiology.