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Diminished illicit drug use as a consequence of long-term methadone maintenance

E Gottheil1, R C Sterling, S P Weinstein

  • 1Department of Psychiatry and Human Behavior, Jefferson Medical College, Philadelphia, PA 19107.

Insights

Methadone maintenance treatment effectively reduces opiate abuse over time. Cocaine use remains a concern but does not escalate other drug abuse in patients undergoing methadone maintenance therapy.

Area of Science:

  • Addiction Medicine
  • Pharmacology
  • Public Health

Background:

  • Methadone maintenance has been a controversial treatment for opiate addiction for 25 years.
  • Concerns about HIV spread among intravenous drug users highlight the importance of effective addiction treatments.

Purpose of the Study:

  • To examine continued illicit substance abuse in patients undergoing methadone maintenance treatment.
  • To assess the relationship between time in treatment and substance abuse patterns.

Main Methods:

  • Analyzed urinalysis results from 229 patients over a 3-month period.
  • Correlated substance use with duration of methadone treatment (3 months to over 10 years).

Main Results:

  • Cocaine use was prevalent and not associated with treatment duration.
  • Cocaine use did not correlate with increased opiate or other illicit drug abuse.
  • Opiate abuse significantly decreased with longer treatment duration, with 85% opiate-free in patients over 10 years in treatment.

Conclusions:

  • Methadone maintenance is an effective treatment for diminishing opiate abuse.
  • Longer duration in methadone treatment is associated with higher rates of opiate abstinence.

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