Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Olfactory dysfunction in the Shy-Drager syndrome

L E Nee1, J Scott, R J Polinsky

  • 1Clinical Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
|August 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of intracoronary saline infusion on dissection during excimer laser coronary angioplasty: a randomized trial. The Percutaneous Excimer Laser Coronary Angioplasty (PELCA) Investigators.

Journal of the American College of Cardiology·1995
Same author

Desmoplastic trichoepithelioma of the upper lip. A case report with histochemical features and observations on its histogenesis.

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics·1995
Same author

Survival, metastasis and recurrence of oral cancer in relation to pathological features.

Annals of the Royal College of Surgeons of England·1995
Same author

Psychological treatments for depression. An update.

The British journal of psychiatry : the journal of mental science·1995
Same author

Microsomal triglyceride transfer protein activity remains unchanged in rat livers under conditions of altered very-low-density lipoprotein secretion.

The Biochemical journal·1995
Same author

School's out ... for family planning.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·1995
Same journal

Cardiovascular pharmacology of dopaminergic agents in humans: a review.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026
Same journal

Vagus nerve stimulation and pulmonary outcomes: a scoping review of preclinical and clinical evidence.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026
Same journal

Haemodynamics of (pre)syncope during carotid sinus massage: a beat-to-beat analysis of haemodynamic parameters during carotid sinus massage.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026
Same journal

Orthostatic hypotension and complaints: not a clear-cut relation.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026
Same journal

Co-occurrence of Chiari malformation type 1 and small fiber neuropathy in a family with a novel COL6A5 null variant.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026
Same journal

Postural tachycardia during active standing: diagnostic criteria in adolescents.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026
See all related articles

Olfactory dysfunction, including anosmia and microsmia, is common in patients with Shy-Drager syndrome (multiple system atrophy). This suggests a potential link between olfactory deficits and the neurodegenerative disease.

Area of Science:

  • Neurology
  • Neuroscience
  • Clinical Medicine

Background:

  • The etiology of Shy-Drager syndrome, now known as multiple system atrophy (MSA), remains unknown.
  • Previous research suggested a preliminary association between environmental-occupational risk factors and MSA.
  • Olfactory dysfunction is a recognized, yet understudied, symptom in neurodegenerative diseases.

Purpose of the Study:

  • To investigate olfactory function in patients with multiple system atrophy (MSA).
  • To explore the potential relationship between olfactory deficits and the progression of MSA.

Main Methods:

  • Olfactory function was assessed in eight patients diagnosed with MSA at various disease stages.
  • A self-administered olfactory test was employed for the assessment.

Related Experiment Videos

  • Patient results were compared against a control group of 203 age- and sex-matched individuals.

    • Main Results:

    • Seven out of eight MSA patients scored below the 39th percentile on the olfactory test compared to controls.
    • Five patients exhibited either total anosmia (complete loss of smell) or microsmia (reduced sense of smell).

    Conclusions:

    • Significant olfactory dysfunction is prevalent in patients with multiple system atrophy (MSA).
    • These findings suggest a potential link between olfactory system impairment and MSA.
    • Further research is warranted to understand the clinical significance of these olfactory abnormalities in MSA.