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Possible implications of Sp1-induced bending of DNA on synergistic activation of transcription
K Ikeda1, K Nagano, K Kawakami
1Department of Biology, Jichi Medical School, Tochigi, Japan.
Gene
|December 22, 1993
Abstract:
We examined DNA bending using an electrophoretic mobility shift assay to determine whether Sp1 induces structural changes in DNA. The results indicated that Sp1 bends DNA upon binding to its recognition sequence. We discuss the possibility that DNA bending is involved in synergistic activation of transcription.