Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dopaminergic modulation of visual sensitivity in man

G Masson1, D Mestre, O Blin

  • 1UA CNRS 1166 "Cognition & Mouvement", Université Aix-Marseille II, France.

Fundamental & Clinical Pharmacology
|January 1, 1993
PubMed
Summary

Dopamine plays a key role in visual processing, modulating contrast sensitivity in the human retina. This neuromodulator influences spatial and dynamic visual properties, impacting light adaptation and motion sensitivity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk factors for the development of in-hospital complications in pluripathological patients.

Revista clinica espanola·2026
Same author

sFlt-1/PlGF ratio use does not reduce hospitalisation duration in suspected preeclampsia: the PRECOG study, a multicentre randomised trial.

Scientific reports·2025
Same author

Carbon impact of orthognathic surgery.

International journal of oral and maxillofacial surgery·2025
Same author

Cannabis for the treatment of amyotrophic lateral sclerosis: What is the patients' view?

Revue neurologique·2023
Same author

Functional connectivity and cognitive changes after donepezil treatment in healthy participants.

Psychopharmacology·2021
Same author

Aminoglycosides in critically ill patients: which dosing regimens for which pathogens?

International journal of antimicrobial agents·2020

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Visual System Research

Background:

  • Dopamine is a neuromodulator in the mammalian retina, influencing photoreceptors and receptive fields.
  • Dopaminergic system disorders, like Parkinson's disease, show visual abnormalities, including altered contrast sensitivity.
  • Previous research suggests dopamine tunes contrast sensitivity in humans.

Purpose of the Study:

  • To investigate the functional significance of dopaminergic modulation on human visual sensitivity.
  • To explore how dopamine affects contrast sensitivity, particularly motion sensitivity.
  • To examine the role of dopamine in light retinal adaptation.

Main Methods:

  • Review of existing literature on dopamine and visual processing.
  • Analysis of psychophysical data from healthy volunteers treated with apomorphine.

Related Experiment Videos

  • Comparison of dopamine-induced contrast sensitivity changes with those observed in Parkinson's disease and schizophrenia.

    • Main Results:

    • Apomorphine administration in healthy volunteers altered contrast sensitivity, with a notable impact on motion sensitivity.
    • Dopamine-induced changes in contrast sensitivity function resemble those seen in Parkinson's disease patients.
    • Similarities between light-induced and dopamine-induced modifications suggest dopamine's role in light adaptation.

    Conclusions:

    • Dopamine significantly modulates human contrast sensitivity, affecting both spatial and dynamic visual properties.
    • Psychophysical evidence supports dopamine's involvement in light retinal adaptation.
    • These findings highlight dopamine's crucial role in fine-tuning visual system sensitivity and function.