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Headaches from chemical exposures

R W Martin1, C Becker

  • 1Department of Medicine, University of California, San Francisco.

Headache
|November 1, 1993
PubMed
Summary
This summary is machine-generated.

Workplace chemical exposures can cause headaches. Accidental, extensive chemical exposure may lead to a new, long-lasting headache syndrome, distinct from routine exposure headaches.

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Area of Science:

  • Occupational Health
  • Neurology
  • Environmental Medicine

Background:

  • Headaches are frequently reported following workplace and environmental chemical exposures.
  • Limited literature exists on headaches specifically linked to occupational chemical exposures.
  • An index case prompted a review and a subsequent study on this topic.

Purpose of the Study:

  • To investigate headaches associated with workplace chemical exposures.
  • To differentiate headache patterns based on the nature and extent of chemical exposure.
  • To characterize a potential new headache syndrome resulting from acute, high-level chemical exposure.

Main Methods:

  • Retrospective descriptive study of 50 subjects referred to University Clinics.
  • Subjects presented with headaches attributed to workplace chemical exposures.

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  • Data collected on exposure characteristics and headache symptoms.

    • Main Results:

    • Low-level, routine chemical exposures typically cause headaches that resolve shortly after exposure cessation.
    • Accidental, extensive chemical exposures can trigger a new headache syndrome with prolonged duration (months to years).
    • Characteristics of this new syndrome include acute, large-quantity exposure, short latency, severe and long-lasting initial headache, and new recurring headaches.

    Conclusions:

    • A distinction exists between headaches from routine versus accidental/extensive chemical exposures.
    • Accidental high-level chemical exposure may cause a distinct, persistent headache syndrome.
    • The proposed term Chemical Headache Exposure Syndrome (CHES) may describe this high-exposure phenomenon.