Related Experiment Videos
Current emergency treatment of severe migraine headaches
1St. Joseph Hospital, Denver, CO 80218.
Objective:
To compare the efficacy of the combination of meperidine and hydroxyzine IM, versus dihydroergotamine and metoclopramide IV in the treatment of severe migraine headaches.
Design:
This was a randomized double-blind, double-dummy study.
Setting:
Established patients, whose headache had failed to respond to their usual abortive agent, were invited to an out-patient headache clinic for the study.
Patients:
Twenty-eight patients, diagnosed as suffering from either migraine headache or chronic daily headache, were screened on arrival to exclude life-threatening causes.
Intervention:
Group A (14 patients) received dihydroergotamine 1mg and metoclopramide 10mg IV and a placebo injection IM, and Group B (14 patients) received meperidine 75mg and hydroxyzine 75mg IM and a placebo injection IV.
Main Outcome Measures:
Patients rated their headaches on a scale of 0-3 prior to treatment and again at 30 and 60 minutes.
Results:
Both groups experienced improvement in headache severity. (Group A P = 0.001 and Group B P = 0.003). Improvement in pain scale score was greater for Group A than Group B. (P = 0.006). The number of patients having a mild or no headache in Group A (13/14) was significantly greater than Group B (3/14). (P < 0.001)
Conclusions:
The combination of dihydroergotamine and metoclopramide IV should replace the standard IM narcotic and anti-emetic as the parenteral treatment of choice for severe migraine headache.