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Synthesis of 3-episiastatin B analogues having anti-influenza virus activity
Y Nishimura1, Y Umezawa, S Kondo
1Institute of Microbial Chemistry, Tokyo, Japan.
The Journal of Antibiotics
|December 1, 1993
Abstract:
Two epimers of siastatin B, 3-episiastatin B (3) and 3,4-diepisiastatin B (4), were obtained by the chemical modification of siastatin B. Compound 3 showed marked inhibitory activity against influenza virus neuraminidases and significant inhibition of influenza virus infection in vitro.