Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Warfarin-induced skin necrosis

¹Department of Pathology, Washington University School of Medicine, St. Louis, Missouri.

Hematology/Oncology Clinics of North America

|December 1, 1993

Summary

Warfarin-induced skin necrosis is a rare complication of oral anticoagulation. This review covers its history, clinical features, and pathophysiology, offering prevention and treatment strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Safety and collection efficiency with a lower transfusion threshold for extracorporeal photopheresis in adult patients with graft-versus-host disease.

Vox sanguinis·2017

Same author

Genetics informatics trial (GIFT) of warfarin to prevent deep vein thrombosis (DVT): rationale and study design.

The pharmacogenomics journal·2011

Same author

Blast flagging with the UniCel DxH 800 Coulter Cellular Analysis System.

Laboratory hematology : official publication of the International Society for Laboratory Hematology·2010

Same author

A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirements in African Americans.

Clinical pharmacology and therapeutics·2010

Same author

Ability of VKORC1 and CYP2C9 to predict therapeutic warfarin dose during the initial weeks of therapy.

Journal of thrombosis and haemostasis : JTH·2009

Same author

Laboratory and clinical outcomes of pharmacogenetic vs. clinical protocols for warfarin initiation in orthopedic patients.

Journal of thrombosis and haemostasis : JTH·2008

Area of Science:

Medical Complications
Pharmacology
Hematology

Background:

Warfarin-induced skin necrosis (WISN) is a rare but severe adverse effect of warfarin therapy.
It is characterized by localized skin and subcutaneous tissue infarction.
WISN is associated with a hypercoagulable state.

Purpose of the Study:

To review the historical, clinical, and pathophysiologic aspects of warfarin-induced skin necrosis.
To discuss current recommendations for the prevention and management of this complication.

Main Methods:

Literature review of historical, clinical, and pathophysiologic data.
Synthesis of evidence regarding prevention and treatment strategies.

Main Results:

WISN is a rare complication linked to protein C deficiency or other thrombophilic states.
Early recognition and management are crucial for minimizing tissue damage.
Management involves discontinuation of warfarin and initiation of alternative anticoagulation.

Conclusions:

Understanding the pathophysiology of WISN is key to its prevention.
Prompt diagnosis and appropriate management can significantly improve patient outcomes.
Further research may elucidate more targeted preventive measures.

Related Experiment Videos