Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple system organ failure: a study of outcome

A Y Phadke1, P G Jiandani

  • 1Dept of Medicine, TNMC & BYL Nair Ch. Hospital, Bombay.

The Journal of the Association of Physicians of India
|August 1, 1993
PubMed
Summary

Multiple System Organ Failure (MSOF) affects 100 patients, with infections and poisoning as common causes. This study introduces a method to predict outcomes in acute MSOF, crucial for patient survival.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acquisition of Helicobacter pylori infection and reinfection after its eradication are uncommon in Indian adults.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology·2000
Same author

Acute lymphoblastic leukemia presenting with severe jaundice in an adult.

The Journal of the Association of Physicians of India·2000
Same author

Predictors of response to pneumatic dilatation in achalasia cardia.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology·2000
Same author

Incomplete tubular duplication of the esophagus lined by heterotopic gastric epithelium, presenting in adulthood.

Endoscopy·2000
Same author

Jejunal stricture complicating acute mesenteric venous thrombosis secondary to protein C deficiency and factor V Leiden gene mutation.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology·2000
Same author

Dental plaque: an unlikely reservoir of Helicobacter pylori.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology·1998

Area of Science:

  • Critical Care Medicine
  • Internal Medicine
  • Pathophysiology

Background:

  • Multiple System Organ Failure (MSOF) is a critical condition with high mortality.
  • Understanding precipitating factors and predicting outcomes are vital for managing MSOF patients.
  • Previous methods for severity evaluation in MSOF may lack reproducibility.

Purpose of the Study:

  • To investigate precipitating factors and outcomes in patients with MSOF.
  • To develop an easily reproducible method for assessing illness severity and predicting outcomes in acute MSOF.
  • To analyze the impact of various organ system failures (OSF) on mortality.

Main Methods:

  • A study of 100 patients diagnosed with Multiple System Organ Failure (MSOF).
  • Analysis of precipitating factors including infections, poisoning, metabolic, surgical disorders, and cardiac arrest.
  • Evaluation of mortality rates based on the number of organ system failures (OSF) and timing of MSOF onset.

Main Results:

  • Overall mortality in the studied MSOF cohort was 65%.
  • Gastrointestinal (GIT), Central Nervous System (CNS), and Liver failures were most common; Respiratory (RS), Cardiovascular (CVS), and CNS failures had the highest mortalities.
  • Mortality increased significantly with the number of OSF, reaching 100% with 6 or 7 OSF. Mortality was highest within the first 48 hours of MSOF.

Conclusions:

  • Acute MSOF presents with diverse precipitating factors and a high overall mortality rate.
  • The number of organ system failures and the timing of MSOF onset are critical determinants of patient outcome.
  • A reproducible method for evaluating MSOF severity and predicting outcomes is proposed, aiding clinical decision-making.

Related Experiment Videos