[Pathophysiology and diagnosis of malignant neoplastic disorders of the hematopoietic system]

The Pathophysiological analysis of hematopoietic tumors has advanced markedly owing to the progress in the fields of histomorphology, biochemistry, hematopoietic stem cells including cytokines, cell surface markers, cytogenetics, and molecular biology. This progress has led to the establishment of many new disease concepts and has almost completely changed the recognition of hematopoietic tumors. These basic studies have also supported the development of effective therapy of hematopoietic tumors. Of course, this progress has been reflected in the techniques and knowledge in routine laboratory evaluation.