Related Experiment Videos
[Skin disorders caused by bismuth oxide (De-Nol)]
J P Ottervanger1, B H Stricker
1Bureau Bijwerkingen Geneesmiddelen, Rijswijk.
Nederlands Tijdschrift Voor Geneeskunde
|January 15, 1994
Summary
Bismuth subcitrate can cause skin reactions like rashes and swelling shortly after starting treatment. All reported cases resolved after discontinuing the drug.
Area of Science:
- Pharmacovigilance
- Dermatology
- Clinical Pharmacology
Background:
- Bismuth subcitrate is a medication used for gastrointestinal conditions.
- Adverse drug reactions require continuous monitoring.
Purpose of the Study:
- To report and analyze skin reactions associated with bismuth subcitrate.
Main Methods:
- Review of adverse drug reaction reports submitted to the Netherlands Centre for Monitoring of Adverse Reactions to Drugs.
- Analysis of patient demographics, reaction types, onset, and outcomes.
Main Results:
- 12 cases of skin reactions (exanthema, angioedema, erythema) linked to bismuth subcitrate were reported.
- Reactions occurred within an average of 2 days of treatment initiation.
- All patients experienced complete recovery upon drug discontinuation.
Conclusions:
- Bismuth subcitrate is associated with a potential risk of cutaneous adverse events.
- Early recognition and cessation of bismuth subcitrate are effective in managing these reactions.