[Aneuploidy frequency in the parthenogenetic activation of mouse tetraploid oocytes by ethyl alcohol]

We studied the frequency of aneuploidy in the parthenogenetic mouse embryos developed from tetraploid oocytes activated by treatment with 80% ethanol solution. The usual diploid mouse oocytes aged in vivo and in vitro were used as the control. Cytogenetic analysis showed that the frequency of aneuploidy in embryos obtained from the tetraploid oocytes (27%) is higher than that in parthenogenotes obtained from diploid oocytes aged in vitro (5%) or in vivo (16%). In the latter case, however, the difference is statistically insignificant. The possible causes of the observed differences are discussed.