Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Malignant hyperthermia

S J Kaus1, M A Rockoff

  • 1Department of Anesthesia, Children's Hospital, Boston, Massachusetts.

Pediatric Clinics of North America
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

Malignant hyperthermia (MH) management has advanced significantly, with mortality rates decreasing due to new therapies and increased awareness. Identifying at-risk individuals and avoiding triggers remain key to reducing MH complications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sedation, risk, and safety: do we really have data at last?

Pediatrics·2001
Same author

Hemostatic changes in pediatric neurosurgical patients as evaluated by thrombelastograph.

Anesthesia and analgesia·2001
Same author

The diagnosis of brain death.

The New England journal of medicine·2001
Same author

Onset and duration of action of rocuronium in children receiving chronic anticonvulsant therapy.

Paediatric anaesthesia·2000
Same author

The effect of propofol on intraoperative electrocorticography and cortical stimulation during awake craniotomies in children.

Paediatric anaesthesia·2000
Same author

Acupressure-acupuncture antiemetic prophylaxis in children undergoing tonsillectomy.

Anesthesiology·1999
Same journal

Barriers, Breakthroughs, and the Future of Pediatric Dermatologic Care.

Pediatric clinics of North America·2026
Same journal

Advancing Pediatric Dermatology: Innovations in Care and Access.

Pediatric clinics of North America·2026
Same journal

No Child Left Behind: Advancing Access in Pediatric Dermatology, a 4-Year, Single-Center Experience.

Pediatric clinics of North America·2026
Same journal

Telemedicine and Access to Pediatric Dermatology Care.

Pediatric clinics of North America·2026
Same journal

Inequitable Reimbursement for Pediatric Providers: A Review of Structural Factors that Disincentivize the Care of Children.

Pediatric clinics of North America·2026
Same journal

Medical Photography's Power to Change Medical Care.

Pediatric clinics of North America·2026
See all related articles

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Genetics

Background:

  • Malignant hyperthermia (MH) is a severe, inherited pharmacogenetic disorder of skeletal muscle.
  • Historically associated with high mortality, particularly during general anesthesia.

Observation:

  • Significant advances in MH management have occurred since its initial description.
  • Deaths secondary to MH have dramatically decreased over the past 15 years.

Findings:

  • Efficacious therapies and increased awareness among healthcare providers and patients have reduced MH mortality.
  • Research has elucidated many pathologic mechanisms, and an animal model aids in testing new therapies.

Implications:

  • Future genetic mapping may offer noninvasive predictive testing for MH susceptibility.

Related Experiment Videos

  • Understanding MH mechanisms could enhance knowledge of anesthetic agent actions.
  • Current primary strategies involve identifying at-risk individuals, avoiding anesthetic triggers, and prompt treatment of MH episodes.