[Effect of Mycobacterium tuberculosis on activity of lysosomal enzymes in mouse peritoneal macrophages]

The studies of the effects produced by M. tuberculosis various strains on the activity of lysosomal enzymes in peritoneal mouse macrophages demonstrated multidirectional influence of the bacilli. Non-sedimentary activity rose in matrical enzymes indicating lysosomal membranes instability due to M. tuberculosis infection followed by hydrolase activation and hydrolases escape into the cytosol. An inhibiting action of pathogenic mycobacteria on lysosomal proteases is suggested.