Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Individual behavioral differences and ethanol consumption in Wistar rats

A Bisaga1, W Kostowski

  • 1Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw, Poland.

Physiology & Behavior
|December 1, 1993
PubMed
Summary

Individual Wistar rats show behavioral differences linked to high ethanol consumption. Specific traits like delayed habituation and altered responses to apomorphine predict increased alcohol intake, suggesting dopaminergic system involvement.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of 5,7-DHT-induced lesions of the median raphe nucleus and chronic desipramine administration upon motor behaviour of rats given intrahippocampal clonidine injection.

Journal of psychopharmacology (Oxford, England)·2011
Same author

Glutamate concentration in whole saliva and taste responses to monosodium glutamate in humans.

Nutritional neuroscience·2006
Same author

Taste responses in patients with Parkinson's disease.

Journal of neurology, neurosurgery, and psychiatry·2004
Same author

Effects of morphine on gene expression in the rat amygdala.

Journal of neurochemistry·2004
Same author

Lack of ifenprodil anxiolytic activity after its multiple treatment in chronically ethanol-treated rats.

Alcohol and alcoholism (Oxford, Oxfordshire)·2003
Same author

Effects of memantine, an NMDA receptor antagonist, on place preference conditioned with drug and nondrug reinforcers in mice.

Behavioural pharmacology·2003

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Pharmacology

Background:

  • Individual differences in behavior exist in Wistar rats.
  • Understanding these differences may explain variations in ethanol consumption.

Purpose of the Study:

  • To investigate if inherent behavioral differences in male Wistar rats influence ethanol intake.
  • To correlate behavioral test outcomes with ethanol consumption levels.

Main Methods:

  • Rats were assessed using various behavioral tests.
  • Ethanol intake was measured and correlated with behavioral data.
  • Apomorphine was administered to assess locomotor responses.

Main Results:

  • Delayed habituation, increased open-field activity post-habituation, and excessive locomotor inhibition to apomorphine predicted high ethanol intake.

Related Experiment Videos

  • Forced swim test, stereotypy, hypothermia, and locomotor stimulation did not predict ethanol preference.
  • Individual behavioral variations correlate with predisposition to high ethanol intake.

    • Conclusions:

    • Behavioral reactivity, particularly delayed habituation and specific responses to apomorphine, is associated with a predisposition for high ethanol consumption in Wistar rats.
    • Individual differences in brain dopaminergic neurotransmission sensitivity may influence the acquisition of high ethanol intake.