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[Method of isolating carbamazepine from cadaveric material and its determination by fluorescent polarization
Sudebno-Meditsinskaia Ekspertiza
|October 1, 1993
Abstract:
Optimal conditions for carbamazepine isolation from cadaveric liver have been determined. The authors recommend the material infusion with alcohol acidified with sulfuric acid to pH 1 three times for an hour. Conditions for measuring the isolated drug quantity have been developed. Fluorescent polarization immunoanalysis in the TDX system has been used for the first time. Carbamazepine detection limit for 50 g of the liver was found to be 2.5 x 10(-7) g.