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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Usefulness of mean aortic valve gradient and left ventricular diastolic filling pattern for distinguishing

S L Archer1, D K Mike, M B Hetland

  • 1Veterans Administration Medical Center, Minneapolis, Minnesota 55417.

The American Journal of Cardiology
|February 1, 1994
PubMed

Insights

Symptomatic men with aortic stenosis have higher aortic gradients and altered diastolic filling patterns compared to asymptomatic individuals. These findings help distinguish between symptomatic and asymptomatic patients with this condition.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Valvular Heart Disease

Background:

  • Aortic stenosis (AS) is a significant valvular heart disease.
  • Distinguishing symptomatic from asymptomatic AS is crucial for management.
  • Understanding the hemodynamic and functional differences is key.

Purpose of the Study:

  • To compare hemodynamic and diastolic function between symptomatic and asymptomatic men with aortic stenosis.
  • To identify predictors of symptom development in patients with AS.

Main Methods:

  • Consecutive men with AS underwent radionuclide angiography at rest and during exercise.
  • Measurements included ejection fraction, diastolic filling, and aortic valve area/gradient.
  • Follow-up assessed symptom status and valve replacement over 2 years.

Main Results:

  • Symptomatic patients had higher mean aortic gradients (53 vs. 37 mm Hg) and lower exercise tolerance.
  • Early diastolic filling was enhanced in symptomatic subjects (shorter time to peak filling rate).
  • Patients who became symptomatic during follow-up showed increased early diastolic filling and higher gradients.

Conclusions:

  • High mean aortic gradients, reduced exercise tolerance, and enhanced early diastolic filling characterize symptomatic AS.
  • These parameters can help differentiate symptomatic from asymptomatic patients.
  • Diastolic dysfunction may play a role in symptom development in AS.

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