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Elevated plasma tissue factor antigen level in patients with disseminated intravascular coagulation
1Second Department of Internal Medicine, Mie University School of Medicine, Japan.
American Journal of Hematology
|March 1, 1994
Summary
Plasma tissue factor (TF) levels are elevated in disseminated intravascular coagulation (DIC) patients, decreasing after treatment. However, TF levels did not correlate with disease severity or patient outcomes in this study.
Area of Science:
- Hematology
- Oncology
- Pathophysiology
Background:
- Disseminated intravascular coagulation (DIC) is a complex syndrome characterized by widespread activation of coagulation.
- Tissue factor (TF) is a known initiator of the coagulation cascade and plays a role in thrombotic disorders.
Purpose of the Study:
- To investigate the role of plasma tissue factor (TF) antigen levels in patients with disseminated intravascular coagulation (DIC).
- To assess the correlation of plasma TF levels with clinical parameters, treatment response, and outcomes in DIC patients.
Main Methods:
- Measurement of plasma TF antigen levels in patients with DIC and healthy volunteers.
- Comparison of TF levels between DIC and non-DIC groups.
- Analysis of TF levels in relation to therapy, organ failure, outcome, and other hemostatic markers.
Main Results:
- Plasma TF antigen was detected in normal volunteers and was significantly higher in DIC patients compared to non-DIC patients.
- Some DIC patients exhibited normal plasma TF antigen levels.
- Plasma TF antigen levels decreased significantly after therapy in DIC patients but showed no correlation with organ failure or outcome.
- Plasma TF levels did not correlate with other hemostatic markers but tended to be higher in DIC patients with nonlymphoid leukemia than those with lymphoid tumors.
Conclusions:
- Plasma TF antigen levels are elevated in DIC and decrease with treatment, suggesting its involvement in the disease process.
- Plasma TF levels are not a reliable indicator of DIC severity, organ failure, or patient prognosis.
- Further research is warranted to elucidate the precise role of TF in the pathogenesis and progression of DIC, particularly in the context of different malignancies.