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p53 and bcl-2 expression in high-grade B-cell lymphomas: correlation with survival time
M A Piris1, F Pezzella, J C Martinez-Montero
1Department of Pathology, Hospital Virgen de la Salud, Toledo, Spain.
British Journal of Cancer
|February 1, 1994
Summary
p53 gene expression significantly impacts survival in B-cell high-grade lymphomas, indicating a poor prognosis. Simultaneous bcl-2 and p53 expression worsens outcomes, especially in nodal lymphomas, suggesting multistep genetic deregulation in non-Hodgkin
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- B-cell high-grade lymphomas exhibit significant heterogeneity.
- Gene deregulations, including bcl-2 and p53, are implicated in lymphoid malignancies.
Purpose of the Study:
- To investigate the relationship between bcl-2 and p53 gene expression and survival probability in B-cell high-grade lymphoma patients.
- To determine the prognostic significance of p53 and bcl-2 expression in lymphoma survival.
Main Methods:
- Analysis of 119 B-cell high-grade lymphoma cases from multiple international centers.
- Assessing the correlation between bcl-2 and p53 protein expression and patient survival.
- Utilizing multivariant regression analysis to identify independent prognostic factors.
Main Results:
- p53 expression significantly correlated with reduced survival probability, independent of histology.
- Extranodal origin was associated with a better prognosis, while p53 expression indicated a poor prognosis.
- Simultaneous bcl-2 and p53 expression conferred a poorer prognosis than p53 alone, particularly in nodal large B-cell lymphomas.
Conclusions:
- p53 expression is a significant independent predictor of poor prognosis in B-cell high-grade lymphomas.
- Combined bcl-2 and p53 expression suggests a cumulative negative impact on survival, supporting multistep genetic deregulation in lymphoma pathogenesis.
- Understanding these genetic deregulations is critical for lymphoma progression and therapeutic strategies.