Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antigen processing: where tumor-specific T-cell responses begin

J R Bennink1, R Anderson, I Bacik

  • 1Laboratory of Viral Diseases, National Institute for Allergy and Infectious Diseases, Bethesda, Maryland 20892.

Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Normal Parathyroid Glands Are Most Often Seen on Neck Ultrasound.

Academic radiology·2024
Same author

Outcomes of active surveillance of EU-TIRADS 5 thyroid nodules.

European journal of endocrinology·2021
Same author

Cystic form of cervical lymphadenopathy in adults. Guidelines of the French Society of Otorhinolaryngology (short version). Part 2-etiological diagnosis procedure: Clinical and imaging assessment.

European annals of otorhinolaryngology, head and neck diseases·2020
Same author

Cystic form of cervical lymphadenopathy. Guidelines of the French Society of Otorhinolaryngology - Head and Neck Surgery (SFORL). Part 1: Diagnostic procedures for lymphadenopathy in case of cervical mass with cystic aspect.

European annals of otorhinolaryngology, head and neck diseases·2019
Same author

TIRADS score is of limited clinical value for risk stratification of indeterminate cytological results.

European journal of endocrinology·2018
Same author

Condensed versus standard schedule of high-dose cytarabine consolidation therapy with pegfilgrastim growth factor support in acute myeloid leukemia.

Blood cancer journal·2017

Tumor-specific CD8+ T cells show promise for cancer treatment. Understanding how these cells recognize tumor peptides bound to major histocompatibility complex class I molecules is key to developing effective cancer immunotherapies.

Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • CD8+ T cells are crucial for anti-tumor immunity.
  • Their therapeutic potential in human cancers is under investigation.
  • Effective manipulation requires understanding tumor antigen presentation.

Purpose of the Study:

  • To provide an overview of peptide-major histocompatibility complex class I complex formation.
  • To highlight recent findings on antigen processing and presentation.
  • To inform strategies for enhancing anti-tumor T-cell responses.

Main Methods:

  • Review of established pathways for antigen processing.
  • Emphasis on cytosolic protein degradation.
  • Analysis of peptide loading onto MHC class I molecules.

Related Experiment Videos

Main Results:

  • CD8+ T cells recognize 8-10 residue peptides.
  • Peptides are derived from cytosolic proteins.
  • Formation of the peptide-MHC class I complex is critical for T-cell recognition.

Conclusions:

  • Understanding antigen presentation is vital for cancer immunotherapy.
  • Recent laboratory findings offer insights into this process.
  • Further research can optimize T-cell based cancer treatments.