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Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
Published on: August 22, 2014
FRAR course on laboratory approaches to aging. Theories of aging
1Andrus Gerontology Center, University of Southern California, Los Angeles 90089-0191.
Abstract:
This review of gerontological theory cites diverse examples of neural and endocrine involvement in the senescence of mammals and some other multicellular species that suggest fundamental involvement in age-related changes in cell functions. The data support the major hypothesis that age-related changes are generally caused by specific physiological factors that are extrinsic to cells. The success of these manipulations includes retarding or reversing specific age-related changes, and extending the life span. From another perspective, these findings have converted time in the analysis of senescence from an independent variable to a dependent variable. So far, we do not need to hypothesize any new mechanism that is not already known in disease or normal functioning.
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