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Purple glove syndrome

M A Helfaer¹, C Ware

¹Division of Pediatric Anesthesiology and Pediatric Intensive Care, Children's Medical and Surgical Center, Johns Hopkins University, Baltimore, Maryland 21287-3711.

Journal of Neurosurgical Anesthesiology

|January 1, 1994

Summary

Purple glove syndrome (PGS) is a rare condition causing skin discoloration and rash. This case links PGS in a child's foot to Dilantin (phenytoin) administration, suggesting a potential adverse reaction.

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Area of Science:

Pediatric Pharmacology
Dermatology
Adverse Drug Reactions

Background:

Purple glove syndrome (PGS) is characterized by discoloration, petechial rash, and induration.
The exact cause of PGS remains unknown, with intravenous extravasation being a leading theory.
Phenytoin (Dilantin) is an anticonvulsant medication with potential for local tissue reactions.

Observation:

A case of PGS occurred in a child's foot.
The reaction was associated with the administration of Dilantin (phenytoin).
Clinical presentation included discoloration and rash consistent with PGS.

Findings:

This report details a specific instance of PGS linked to phenytoin administration.
The location of the reaction in the foot is noteworthy.
The case contributes to understanding potential etiologies of PGS.

Implications:

This case suggests phenytoin may be an iatrogenic cause of Purple Glove Syndrome.
Further investigation into phenytoin's role in PGS is warranted.
Clinicians should be aware of this potential adverse reaction when administering phenytoin, especially in pediatric patients.

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