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Inhibition of NF-kappa B DNA binding activity by alpha-tocopheryl succinate
1Department of Molecular & Cell Biology, University of California, Berkeley 94720.
Biochemistry and Molecular Biology International
|November 1, 1993
Abstract:
Vitamin E derivatives have been shown to inhibit tumor necrosis factor-induced NF-kappa B activation in human Jurkat T cells. The present report demonstrates that alpha-tocopheryl succinate directly blocks DNA binding activity of activated NF-kappa B, as well as the NF-kappa B activation induced by okadaic acid, an inhibitor of protein phosphatases 1 and 2A. In contrast, alpha-tocopherol, alpha-tocopheryl acetate and 2,2,5,7,8-pentamethyl-6-hydroxychromane have no effects. These observations suggest that the mechanism of alpha-tocopheryl succinate action against NF-kappa B is different from those of other vitamin E derivatives.