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Related Experiment Videos

Pulmonary function changes 100 days and one year after bone marrow transplantation

M Badier1, C Guillot, S Delpierre

  • 1Respiratory Laboratory, Sainte Marguerite Hospital, Marseille, France.

Bone Marrow Transplantation
|November 1, 1993
PubMed
Summary

Pulmonary function tests after bone marrow transplantation (BMT) reveal significant lung capacity and function changes. Frequent monitoring is crucial for early detection and management of lung complications post-BMT.

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Area of Science:

  • Pulmonary Medicine
  • Hematology
  • Oncology

Background:

  • Bone marrow transplantation (BMT) can lead to pulmonary complications.
  • Pre-existing lung conditions and treatment regimens influence pulmonary function.
  • Understanding post-BMT lung changes is vital for patient outcomes.

Purpose of the Study:

  • To assess pulmonary function changes in patients undergoing autologous and allogeneic BMT.
  • To identify factors influencing lung function decline after BMT.
  • To evaluate the relationship between lung function changes and mortality.

Main Methods:

  • Prospective study of 117 patients undergoing BMT.
  • Pulmonary function tests (total lung capacity, transfer coefficient) performed pre-BMT, 100 days post-BMT, and 1 year post-BMT.

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  • Analysis of factors including disease status, prior pulmonary issues, chemotherapy, and graft-versus-host disease (GVHD).

    • Main Results:

    • Pre-BMT, slight reductions in total lung capacity (TLC) and transfer coefficient (KCO) were observed.
    • 100 days post-BMT, TLC decreased by 5% and KCO by 8%, influenced by BMT type and GVHD.
    • One year post-BMT, KCO significantly dropped in both groups; TLC decrease was more pronounced in autologous BMT patients.
    • Relapse and lung function changes correlated with mortality.

    Conclusions:

    • Pulmonary function undergoes significant changes after BMT, varying by transplant type.
    • Factors like GVHD, disease relapse, and pre-existing conditions impact lung health.
    • Regular pulmonary function testing is essential for monitoring and managing post-BMT lung complications.