Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Colonic vasoactive intestinal polypeptide in ulcerative colitis

C Surrenti1, D Renzi, M R Garcea

  • 1Department of Clinical Pathophysiology, University of Florence, Italy.

Journal of Physiology, Paris
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring ex vivo biofilm dynamics: consequences of low ampicillin concentrations on the human oral microbiome.

NPJ biofilms and microbiomes·2024
Same author

Characterization of a Signaling System in Streptococcus mitis That Mediates Interspecies Communication with Streptococcus pneumoniae.

Applied and environmental microbiology·2018
Same author

Antibiotics alter the window of competence for natural transformation in streptococci.

Molecular oral microbiology·2018
Same author

High-resolution profiles of the Streptococcus mitis CSP signaling pathway reveal core and strain-specific regulated genes.

BMC genomics·2018
Same author

BEAM vs FEAM high-dose chemotherapy: retrospective study in lymphoma patients undergoing autologous stem cell transplant.

Bone marrow transplantation·2018
Same author

The usefulness of sLORETA in evaluating the effect of high-dose ARA-C on brain connectivity in patients with acute myeloid leukemia: an exploratory study.

Functional neurology·2018

Vasoactive intestinal polypeptide (VIP) levels are significantly reduced in the colonic mucosa of ulcerative colitis patients. This decrease in VIP may influence inflammatory responses and disease activity in the gut.

Area of Science:

  • Neurogastroenterology
  • Immunology
  • Gastroenterology

Background:

  • Vasoactive intestinal polypeptide (VIP) is a peptide found in the nervous system with known effects on intestinal functions, including secretion, motility, and immune cell activity.
  • Alterations in VIP concentrations have been hypothesized to influence intestinal inflammation, but findings in ulcerative colitis (UC) patients are conflicting.

Purpose of the Study:

  • To investigate the concentration of VIP in the rectal and colonic mucosa of patients with ulcerative colitis (UC) compared to controls.
  • To determine if changes in VIP levels correlate with the degree of mucosal inflammation in UC.

Main Methods:

  • Radioimmunoassay was used to measure VIP concentrations in rectal and colonic mucosal biopsies.
  • Concentrations of substance P and calcitonin gene-related peptide were also measured to assess selectivity.

Related Experiment Videos

Main Results:

  • A significant decrease in VIP concentration was observed in the rectal and colonic mucosa of UC patients compared to healthy controls.
  • The reduction in VIP was selective, as other neuropeptides (substance P, calcitonin gene-related peptide) remained unchanged.
  • The observed decrease in VIP levels correlated with the degree of mucosal inflammation in UC patients.

Conclusions:

  • The study demonstrates a significant reduction of VIP in the colonic mucosa of ulcerative colitis patients.
  • This VIP reduction, while potentially non-specific, may play a role in modulating local inflammatory responses and influencing the overall activity of ulcerative colitis.