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[D-xilose test during 3 hours. Dose standardization ]

J P De Moraes Filho, N Bonini, A Sipahi

    G.E.N
    |July 1, 1976
    PubMed
    Summary
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    The D-xylose absorption test can be shortened to three hours, using a 5g dose. This 5g dose effectively differentiates healthy individuals from those with intestinal diseases, with no observed side effects.

    Area of Science:

    • Gastroenterology
    • Clinical Diagnostics

    Background:

    • Malabsorption syndromes present diagnostic challenges.
    • Accurate and efficient diagnostic tests are crucial for patient management.

    Purpose of the Study:

    • To evaluate the efficacy of a 3-hour urinary D-xylose test.
    • To determine the optimal D-xylose dose for differentiating healthy individuals from patients with intestinal disorders.

    Main Methods:

    • Urinary D-xylose excretion was measured at 3 and 5 hours post-ingestion.
    • Two doses (5g and 25g) of D-xylose were administered.
    • Participants included 13 healthy controls and 7 patients with confirmed steatorrhea and enteric lesions.

    Main Results:

    • A 3-hour test with either 5g or 25g D-xylose effectively distinguished controls from patients.

    Related Experiment Videos

  • The 5g dose showed no adverse side effects, unlike the 25g dose which caused side effects in 30% of patients.
  • Under 3-hour conditions, 95% of controls excreted <1.030g (21%) of the 5g D-xylose dose.

    • Conclusions:

    • The 5g D-xylose dose in a 3-hour urinary excretion test is a safe and effective method for diagnosing intestinal malabsorption.
    • Shortening the test duration to 3 hours improves efficiency without compromising diagnostic accuracy.